The quarter-final line-up for the Champions League will be completed this week, with Tuesday's ties both finely balanced.
Manchester United had David de Gea to thank for a battling 0-0 draw in Sevilla, but will be hoping to spend more time on the front foot at Old Trafford.
Roma have the benefit of an away goal from the first leg against Shakhtar Donetsk, but will need to score at least once to progress after losing 2-1.
Here we look at some of the best Opta numbers ahead of the two matches.
Roma v Shakhtar Donetsk
4 - Shakhtar Donetsk have won four of their five competitive games against Roma (L1), all in the Champions League.
52 - More than half of the teams who lose the first leg of a Champions League knockout game away from home 2-1 end up progressing (52 per cent - 12/23).
4 - However, Roma have been eliminated from all four Champions League knockout ties in which they have lost the first leg (home or away).
1 - The Ukrainian side are aiming to reach the Champions League quarter-finals for the first time since the 2010-11 campaign – which they did so by beating Roma 6-2 on aggregate in the round of 16.
3 -The Italian side have kept a clean sheet in each of their last three Champions League home games, winning the last two (D1).
Manchester United v Sevilla
1 - Manchester United have only lost one of their last nine home Champions League games against Spanish sides (W5 D3), that came against Real Madrid at this stage in 2012-13.
70 - Of the away sides who have drawn the first leg of a Champions League knockout tie 0-0, 70 per cent end up progressing to the next round (21/30).
15 - Manchester United haven't managed to score more than one goal in any of their last 15 Champions League encounters with Spanish opposition (seven goals in total).
0 - Sevilla have never won a Champions League game in England (D1 L3), with that one draw coming at Liverpool in this season's group stages.
1 - Starting with the 2011 final, Manchester United have only won one of their last eight Champions League knockout games (D3 L4).
7 - Jose Mourinho has only lost seven of his previous 69 Champions League home games as manager (W48 D14), though five of those defeats have been against Spanish opposition.
|Stade beat Ospreys on emotional Chauvin tribute night|
|Ligue 1 survival bid a marathon not a sprint for Monaco, as club appoints distance runner|
|Vertonghen eyeing Spurs future beyond 2020|
|De Bruyne injuries could be a blessing for City, says Guardiola|
|Emery prepared to face Arsenal´s centre-back crisis|
|Ulster complete Scarlets double, Exeter gain Gloucester revenge|
|Sheffield United 1 West Brom 2: Baggies comeback boosts automatic promotion push|
|Del Potro back on court following knee injury|
|Canelo v Fielding: Rocky ready to write his own fairytale in New York|
|Boca part company with Schelotto after Copa Libertadores loss to River|
|Canelo v Fielding: Tale of the tape|
|Juventus defender Cancelo has knee surgery|
|Canelo v Fielding: Alvarez and Rocky make weight in New York|
|Spalletti does not fear another mid-season crisis at Inter|
|Salah headlines CAF Player of the Year shortlist as Koulibaly misses out|
|Beckham Jr. out of Titans clash|
|Lipsky hits the front at Leopard Creek|
|Pederson coy over Wentz back injury|
|Liverpool ´not really likely´ to be active in January window, reveals Klopp|
|Always on the move and unpredictable - Pavard reveals surprising choice over toughest opponent|
|We need to get back to respect - Lampard alarmed by hate in football|
|Giles returns to England to replace Strauss as director|
|Hansen has no issue with Milner-Skudder Toulon switch|
|Juventus to rest Ronaldo after Torino showdown|
|Titmus strikes gold again as world records tumble in Hangzhou|
|Malinga to captain Sri Lanka in New Zealand|
|Rivaldo would like ´excellent´ Isco at Barcelona|
|United a long way from Mourinho´s vision|
|´Klopp denies an answer!´ - Liverpool boss dismisses questions about ´world-class´ Pogba|
|Returning Nowitzki ´so tired´ after making NBA history|
|Aguero and De Bruyne in contention for Manchester City v Everton|
|Simeone has no plans to cash in on Costa|
|Canelo v Fielding: Alvarez´s greatest nights|
|Fabregas: Chelsea being unfairly scapegoated over racism allegations|
|Crisis? What crisis? Klopp focuses on defensive solutions for United clash|
|Hope cannot inspire Windies as Bangladesh cruise to series win|
|Benitez picks up Premier League Manager of the Month award|
|Chavez, Marquez and Canelo - Mexico´s greatest multi-weight world champions|
|Bale set to miss Real Madrid v Rayo Vallecano|
|Robben out until January as Bayern look to avoid serious injury|
|Milan avoid UEFA ban in FFP punishments.|
|Mourinho compares Liverpool to ´an amazing house´ but insists trophies matter|
|Brisbane Roar 2 Melbourne Victory 4: Muscat´s men hit A-League summit|
|Bumrah confident second Test is ´in the balance´ after India recovery|
|Isco gesture was for a corner or foul, claims Solari|
|Harris leads Australia into ascendancy on day one|
|ATP announces candidates to host future Finals|
|Ronaldo: Juventus fans refuse to lose to Torino|
|Hero Rivers feared he had cost Chargers in KC|
|Williams would welcome Llorente back to Athletic Bilbao|
|Liverpool v Manchester United: Minding the gap|
|Milan elimination unjust, fumes Leonardo|
|Paul hails ´sick´ Harden after record-breaking display|
|Liverpool v Manchester United: Salah, Mane and Firmino v Rashford, Martial and Lukaku in Opta number|
|Canelo open to GGG trilogy as he chases place in Mexican history|
|The big Friday Premier League quiz|
|Harden posts record fourth 50-point triple-double in win over Lakers|
|Barcelona squad happy with Dembele, says Alba|
|Chargers rally past Chiefs to clinch playoff spot|
|WATCH: Chargers top Chiefs on dramatic two-point conversion in final seconds|
|Suns owner Sarver committed to keeping team in Phoenix|
|Chargers WR Allen leaves with injury after near-spectacular catch|
|Socceroos not giving up on Mooy for Asian Cup|
|Cooper says Raiders owner wanted to trade him to Cowboys|
|Pochettino jokes Levy is ´worried´ about losing him|
|Barcelona would welcome Morata – Alba|
|Toure not a priority for West Ham – Pellegrini|
|Koscielny no certainty to face Southampton, says Emery|
|We gifted the game – AC Milan boss Gattuso furious after Europa League exit|
|My season starts now, says Koscielny|